Meanings of 12 vs 21

Hi, Im curious if someone has some insight into the difference between the meanings of 12 and 21? I feel like they represent different things, however cant figure out how or why as they both include the numbers 1 and 2, and contribute to create 3. Is it just as basic as the order – 12 including 1 as its lead, and 21 containing 2 as its lead?

Would love to hear your opinions!

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